Postdoctoral research fellow and graduate student positions are available in Dr. Ken Cho's lab to study 1) gene regulatory network (GRN) controlling endoderm formation in Xenopus tropicalis, and 2) preimplantation development in mice. Please visit "Research" for more information about our research. (posted April, 2016)
Owens et al., Cell Reports, 2016
Biology has reached the state that quantitative measurements are required to describe biological phenomenon by theoretical models. Such data are difficult to obtain from living embryos. Ken Cho’s lab (Dev and Cell Biology), together with colleagues at Yale U. (New Haven CT) and the Crick Institute (London UK) published a study in Cell Reports on their genomewide analysis of mRNAs over an extended timecourse of early vertebrate embryogenesis. The group has successfully quantitated all mRNA expression in living embryos for the first 3 day of development from the western clawed frog Xenopus tropicalis. This time window corresponds to approximately the first 8 weeks of human gestation, a very difficult period to examine embryonic development. Determination of absolute mRNA numbers and kinetics of their accumulation will uncover the critical mechanisms controlling embryonic development.
Our works were highlighted in "At new heights – endodermal lineages in development and disease." by Elke A. Ober and Anne Grapin-Botton, Development (2015) 142, 1912, and also in "The embryo reunited with its membranes in Goettingen, Germany" by Claudio Stern, Development (2015), 142:2727.